GLP-1
The drug class that ate the endocrinology textbook, told one patient-year at a time.
What started as a type-2 diabetes injectable is now the largest pharmacological intervention in modern weight management. The GLP-1 desk covers the trial data, the prescribing questions, the muscle-and-bone debates, and the long tail of patients who are not in any trial at all.
GLP-1 GLP-1s and Exercise: Better Together
The biggest results do not come from the drug alone. Here is what the evidence says about pairing a GLP-1 with training — and why the combination beats either one by itself.
GLP-1 GLP-1s and the Willpower Myth
Obesity was framed for decades as a failure of discipline. The biology — and the drugs that act on it — tell a different story. Here is why "just eat less" was always the wrong advice.
GLP-1 How GLP-1 Medications Actually Work
A plain-language look at what semaglutide, tirzepatide, and related drugs do inside the body, what the big trials showed, and where the science is still uncertain.
GLP-1 Managing the Most Common GLP-1 Side Effects
Nausea, diarrhea, vomiting, and constipation are the most common effects of semaglutide and tirzepatide. Here is what the trial evidence shows, and the practical steps experts recommend.
GLP-1 What Happens When You Stop Taking a GLP-1
A plain-language look at what the research actually says about weight regain and fading health gains after stopping semaglutide or tirzepatide — and why researchers call it biology, not a personal failure.
GLP-1 GLP-1 Dosing and Titration: Why You Start Low
A plain-language look at why semaglutide and tirzepatide begin at doses too small to treat — and what the drug labels and clinical trials say about ramping up slowly.
GLP-1 Who Is (and Isn't) a Candidate for GLP-1 Medications
A plain-language look at who fits the eligibility criteria for weight-management drugs like Wegovy and Zepbound — and who the labels say should not take them.